serine/threonine protein kinase A-Raf; proto-oncogene A-Raf; proto-oncogene A-Raf-1; proto-oncogene Pks (ARAF, ARAF1, PKS, PKS2)

Function

• role in the transduction of mitogenic signals from the cell membrane to the nucleus
• interacts with TH1L/NELFD

Cofactor: binds 2 Zn+2 per subunit (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, RAF subfamily
• contains 1 phorbol-ester/DAG-type Zn+2 finger
• contains 1 protein kinase domain
• contains 1 RBD (Ras-binding) domain

Expression

• predominantly in urogenital tissues (e.g. ovaries, epididymis & urinary bladder)

More general terms

• raf proto-oncogene protein or mil proto-oncogene protein
• zinc finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=369
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:369
• OMIM: https://mirror.omim.org/entry/311010
• UniProt: http://www.uniprot.org/uniprot/P10398.html