PR domain zinc finger protein 5; PR domain-containing protein 5 (PRDM5, PFM2)

Function

• sequence-specific DNA-binding transcription factor
• represses transcription at least in part by recruitment of histone methyltransferase EHMT2/G9A & histone deacetylases such as HDAC1
• regulates hematopoiesis-associated protein-coding & microRNA (miRNA) genes
• may regulate the expression of proteins involved in extracellular matrix development & maintenance, including fibrillar collagens, such as COL4A1 & COL11A1, connective tissue components, such as HAPLN1, & molecules regulating cell migration & adhesion, including EDIL3 & TGFB2
• may cause G2/M arrest & apoptosis in cancer cells
• interacts with EHMT2/G9A, GFI1 & HDAC1

Structure

• contains 16 C2H2-type Zn+2 fingers
• contains 1 SET domain

Compartment

nucleus

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highest levels in colon & ovary
• tends to be silenced in breast, colorectal, gastric & liver cancer tissues

Pathology

• defects in PRDM5 are the cause of brittle cornea syndrome type 2

More general terms

• C2H2 type zinc finger protein
• DNA-binding protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=11107
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:11107
• OMIM: https://mirror.omim.org/entry/614161
• OMIM: https://mirror.omim.org/entry/614170
• UniProt: http://www.uniprot.org/uniprot/Q9NQX1.html