interferon-induced helicase C domain-containing protein 1; clinically amyopathic dermatomyositis autoantigen 140 kDa; CADM-140 autoantigen; helicase with 2 CARD domains; Helicard; interferon-induced with helicase C domain protein 1; melanoma differentiation-associated protein 5; MDA-5; murabutide down-regulated protein; RNA helicase-DEAD box protein 116 (IFIH1, MDA5, RH116)

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Function

RNA helicase that, through its ATP-dependent unwinding of RNA, may function to promote message degradation by specific Rnases
seems to have growth suppressive properties
role in innate immune defense against viruses
upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 & IRF7 & the induction of the expression of antiviral cytokines such as IFN-beta & RANTES (CCL5)
ATPase activity is specifically induced by dsRNA
essential for the production of interferons in response to picornaviruses
during apoptosis, processed into 3 cleavage products
the helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus
the processed protein significantly sensitizes cells to DNA degradation (putative)
interacts with MAVS
interacts with V protein of simian virus 5, human parainfluenza virus 2, Mumps virus, Sendai virus & Hendra virus
binding to paramyxoviruses V proteins prevents IFN-beta induction, & the further establishment of an antiviral state.
interacts with PCBP2
interacts with NLRC5

genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19
IFIH1 is the CADM-140 autoantigen found in patients with amyopathic dermatomyositis
in HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great increase in the level of secreted viral p24 protein