aberrantly expressed proteins/genes in cancer
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Introduction
genes/proteins aberrantly expressed in cancers (general) (just a prototype, see specific type of cancer)
Expression
- overexpression: EXOSC5, HORMAD1 (carcinomas), HSPH1
- aberrant expression of USP6
- CHP2 is expressed in malignantly transformed cells
- CHFR is silenced in many primary cancers because of CpG methylation & deacetylated histones on its promoter region
Pathology
- chromosomal translocation t(9;15)(q34;q14) involving BRD3 with NUT is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
- t(9;15)(q34;q14 produces a BRD3-NUT fusion protein[1]
chromosomal translocation t(15;19)(q14;p13) involving NUT with BRD4 is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
- translocation produces a BRD4-NUT fusion protein[2]
More general terms
Additional terms
References
- ↑ 1.0 1.1 UniProt http://www.uniprot.org/uniprot/Q15059.html
- ↑ 2.0 2.1 UniProt http://www.uniprot.org/uniprot/O60885.html