bromodomain-containing protein 4; protein HUNK1 (BRD4, HUNK1)

Function

• chromosomal dynamics during mitosis
• associated with chromosomes during mitosis
• recognizes acetylated residues on histones

Pathology

• interacts with bovine papillomavirus type 1 regulatory protein E2
• chromosomal translocation t(15;19)(q14;p13) involving BRD4 with NUT is found in a rare, aggressive, & lethal carcinoma arising in midline organs of young people
• t(15;19)(q14;p13) produces a BRD4-NUT fusion protein

Pharmacology

• anti-tubulin drugs disrupt BRD4 chromosomal interactions

More general terms

• Bromodomain-containing protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23476
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23476
• OMIM: https://mirror.omim.org/entry/608749
• UniProt: http://www.uniprot.org/uniprot/O60885.html