calcineurin B homologous protein 2; hepatocellular carcinoma-associated antigen 520 (CHP2, HCA520)

Function

• binds to & activates SLC9A1/NHE1, thus increasing pH
• protects cells from serum deprivation-induced death
• binds to SLC9A1/NHE1

Structure

contains 4 EF-hand domains

Expression

• not detected in normal tissues

Pathology

• expressed in malignantly transformed cells

More general terms

• myristoylated protein
• Ca+2 binding protein

Additional terms

• aberrantly expressed proteins/genes in cancer
• calcineurin-B or phosphatase-3 (2B) regulatory subunit

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=63928
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:63928
• UniProt: http://www.uniprot.org/uniprot/O43745.html