HOXB-AS3 peptide (HOXB-AS3)

Function

• blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif
• this inhibits inclusion of exon 9 & promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform & promoting production of the M1 isoform
• also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a)
• promotes MYC stability through interaction with IGF2BP2
• interacts with HNRNPA1 (via the RGG-box)
• interacts with IGF2BP2

Notes

• by blocking HNRNPA1-dependent PKM splicing, inhibits colon cancer cell aerobic glycolysis & suppresses colon cancer cell growth, colony formation, migration & invasion
• promotes proliferation & viability of oral squamous cell carcinoma cells

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/C0HLZ6.html