metageria

Clinical manifestations

• premature skin aging
  • scaring of his fingers
  • fibrosing contractures on the phalanges
• eunuch-like stature, bird-like face, exophthalmos
• bilateral posterior cataract
• hypogonadism

Laboratory

• serum glucose, glucose tolerance test
  • impaired glucose tolerance, diabetes mellitus
• uric acid in serum: hyperuricemia
• protein in urine proteinuria

Radiology

• ankylosis & osteoporosis of the phalanges & carpals

More general terms

• progeroid syndrome