secreted Ly-6/uPAR domain-containing protein 2; secreted LY6/PLAUR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; SLURP-2 (SLURP2)

Function

• binds & may modulate function of acetylcholine receptors,
  • nicotinic receptors & muscarinic receptors
• may regulate keratinocyte proliferation, differentiation & apoptosis
• in vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2- containing nAChRs & strongly these of alpha-4: beta-2-containing nAChRs
• modulates alpha-7-containing nAChRs, & inhibits nicotine- induced signaling probably implicating alpha-3:beta-4- containing nAChRs
• proposed to act on alpha-3:beta-2 & alpha-7 nAChRs in an orthosteric, & on mAChRs, such as CHRM1 & CHRM3, in an allosteric manner
• interacts with CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB2 & CHRNB4
• interacts with CHRM1 & CHRM3 probably in an allosteric manner

Compartment

secreted

Expression

• expressed cervix & esophagus > adult & fetal skin > brain, lung, stomach, small intestine, colon, rectum, uterus, & thymus
• not detected in spleen or bone marrow
• in the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level)
• in attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level)
• detected in serum (at protein level)
• up-regulation by IL-22 is suppressed by IFN-gamma (at protein level)

Pathology

• expression is up-regulated 3-fold in psoriatic lesional skin

More general terms

• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=66004
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:66004
• OMIM: https://mirror.omim.org/entry/606110
• UniProt: http://www.uniprot.org/uniprot/P0DP57.html