nicotinic receptor alpha-4; neuronal acetylcholine receptor subunit alpha-4 (CHRNA4, NACRA4)

Function

• nicotinic receptor alpha subunit
• forms neuronal nicotinic receptors with CHRNB2, CHRNB3 & CHRNB4
• interaction with RIC3 is required for proper folding & assembly

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Pathology

• defects in CHRNA4 are the cause of nocturnal frontal lobe epilepsy type 1

More general terms

• nicotinic receptor alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1137
• OMIM: https://mirror.omim.org/entry/118504
• OMIM: https://mirror.omim.org/entry/600513
• UniProt: http://www.uniprot.org/uniprot/P43681.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1137