nicotinic receptor beta-2; neuronal acetylcholine receptor subunit beta-2 (CHRNB2)

Function

• nicotinic receptor beta CHRNB2 can be combined to CHRNA2, CHRNA3, CHRNA4 to form functional nicotinic receptors
• interaction with RIC3 is required for proper folding & assembly

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Pathology

• defects in CHRNB2 are the cause of nocturnal frontal lobe epilepsy type 3 (ENFL3

More general terms

• nicotinic receptor beta subunit

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1141
• OMIM: https://mirror.omim.org/entry/118507
• OMIM: https://mirror.omim.org/entry/605375
• UniProt: http://www.uniprot.org/uniprot/P17787.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1141