nicotinic receptor alpha-3; neuronal acetylcholine receptor subunit alpha-3 (CHRNA3, NACHRA3)

Function

• nicotinic receptor alpha
• forms neuronal nicotinic receptors with CHRNB2, CHRNB3 & CHRNB4
• interaction with RIC3 is required for proper folding & assembly

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

cell junction, synapse, postsynaptic cell membrane

Alternative splicing

named isoforms=2

Pathology

• genetic variations in CHRNA3 may be associated with
  • susceptibility to lung cancer type 2
  • peripheral arterial occlusive disease type 2

More general terms

• nicotinic receptor alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1136
• OMIM: https://mirror.omim.org/entry/118503
• OMIM: https://mirror.omim.org/entry/612052
• UniProt: http://www.uniprot.org/uniprot/P32297.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1136