protein RIC-3 (RIC3)

Function

• promotes functional expression of homomeric alpha-7 & alpha-8 nicotinic acetylcholine receptors at cell surface
• may promote functional expression of homomeric serotoninergic 5-HT3 receptors, & of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 & alpha-4/beta-4
• interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 & HTR3A

Structure

belongs to the ric-3 family

Compartment

• isoform 1: endoplasmic reticulum membrane
• isoform 2: endoplasmic reticulum membrane, Golgi membrane

Alternative splicing

named isoforms=5

Expression

• broadly expressed, with high levels in muscle, brain & heart

Pathology

• overexpressed in brains from patients with bipolar disease or schizophrenia

More general terms

• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q7Z5B4.html