serotonin [5HT]-3A receptor; 5-hydroxytryptamine receptor 3A; 5-HT3R; 5-HT3A; 5-HT-3; serotonin receptor 3A; serotonin-gated ion channel receptor (HTR3A, 5HT3R, HTR3)

Function

• one of the several receptors for 5-hydroxytryptamine (serotonin)
• ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons
• cation-specific, but otherwise relatively nonselective, ion channel
• forms pentahomomeric complex as well as pentaheteromeric complex with HTR3B or HTR3C or HTR3D or HTR3E
• homomeric complexes are functional but exhibit low conductance, decreased agonist & antagonist affinity with modified voltage dependence
• interacts with RIC3

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family
• the HA-stretch region of HTR3A seems to be responsible for the low conductance of HTR3A homomers compared to that of HTR3A/HTR3B heteromers

Compartment

• cell junction, synapse, postsynaptic cell membrane

Alternative splicing

named isoforms=2

Expression

• expressed in cerebral cortex, amygdala, hippocampus, & testis
• detected in monocytes of the spleen & tonsil, in small & large intestine, uterus, prostate, ovary & placenta

More general terms

• transmembrane 4e protein
• serotonin [5HT]-3 receptor
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3359
• OMIM: https://mirror.omim.org/entry/182139
• UniProt: http://www.uniprot.org/uniprot/P46098.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3359