serotonin [5HT]-3B receptor; 5-hydroxytryptamine receptor 3B (5-HT-3B, 5-HT3B, HTR3B)
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Function
- one of several different receptors for 5-hydroxytryptamine (serotonin)
- ligand-gated ion channel, which when activated causes fast, depolarizing responses
- cation-specific, but otherwise relatively nonselective, ion channel
- forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional
Structure
- belongs to the ligand-gated ionic channel (TC 1.A.9) family
- HA-stretch region of HTR3B seems to be confer increased conductance to HTR3A/HTR3B heteromers compared to that of HTR3A homomers
Compartment
- cell membrane
- presumably retained within the endoplasmic reticulum unless complexed with HTR3A
Alternative splicing
named isoforms=2
Expression
- expressed in the brain cortex, in the caudate nucleus, the hyppocampus, the thalamus & the amygdala
- detected in the kidney & testis as well as in monocytes of the spleen, small & large intestine, uterus, prostate, ovary & placenta