5-hydroxytryptamine receptor 3D (serotonin receptor 3D, 5-HT3D, HTR3D)

Function

• one of several different receptors for 5-hydroxytryptamine (serotonin)
• ligand-gated ion channel, which when activated causes fast, depolarizing responses
• cation-specific, but otherwise relatively nonselective, ion channel
• forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell membrane
• presumably retained within the endoplasmic reticulum unless complexed with HTR3A

Alternative splicing

named isoforms=3

Expression

• expressed in liver, & fetal & adult colon & kidney

More general terms

• transmembrane 4e protein
• glycoprotein
• serotonin [5HT]-3 receptor

Database

• UniProt: http://www.uniprot.org/uniprot/Q70Z44.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9177