5-hydroxytryptamine receptor 3E (serotonin receptor 3E, 5-HT3E, HTR3E)

Function

• one of several different receptors for 5-hydroxytryptamine (serotonin)
• ligand-gated ion channel, which when activated causes fast, depolarizing responses
• cation-specific, but otherwise relatively nonselective, ion channel
• forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell membrane
• presumably retained within the endoplasmic reticulum unless complexed with HTR3A

Alternative splicing

named isoforms=5

Expression

expressed in adult colon & intestine

More general terms

• transmembrane 4e protein
• glycoprotein
• serotonin [5HT]-3 receptor

Database

• UniProt: http://www.uniprot.org/uniprot/A5X5Y0.html