nicotinic receptor alpha-2; neuronal acetylcholine receptor subunit alpha-2 (CHRNA2)

Function

• nicotinic receptor alpha subunit
• forms neuronal nicotinic receptors with CHRNB2, CHRNB3 & CHRNB4

Structure

• belongs to the ligand-gated ionic channel (TC 1.A.9) family

Compartment

• cell junction, synapse, postsynaptic cell membrane

Pathology

• defects in CHRNA2 are the cause of nocturnal frontal lobe epilepsy type 4

More general terms

• nicotinic receptor alpha

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1135
• OMIM: https://mirror.omim.org/entry/118502
• OMIM: https://mirror.omim.org/entry/610353
• UniProt: http://www.uniprot.org/uniprot/Q15822.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1135