pyrin domain-containing protein 2-like protein POP4; NLR family & pyrin domain-containing 2 pseudogene; pyrin-only protein 4 (NLRP2P, CLRX1, NOD24, POP4)

Function

• may function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thus inhibiting its transcriptional activity
• may control cytokine release upon Toll-like receptors activation & therefore play a role in modulation of innate immunity
• may play a role in cell cycle progression & apoptosis

Compartment

• cytoplasm, nucleus
• targeted to the nucleus upon TNF-alpha treatment

Expression

• expressed in all tissues tested, including spleen, lymph nodes, thymus, tonsil, peripheral blood leukocytes, bone marrow, liver, heart, brain, placenta, lung, skeletal muscle, kidney & pancreas
• expressed in fetal liver
• induced by inflammatory stimulus (LPS)

Genetics

• likely derived from retrogene insertion of an NLRP2/NLRP7- like gene
• originally considered a pseudogene

More general terms

• uncharacterized protein

Database

• UniProt: http://www.uniprot.org/uniprot/P0DMW2.html