NACHT, LRR & PYD-containing protein 7; PYRIN-containing APAF1-like protein 3 (NALP7, NLRP7, NOD12, PYPAF3)

Function

• inhibits CASP1/caspase-1-dependent IL1B secretion
• interacts with CASP1 & IL1B

Structure

• contains 1 DAPIN domain contains 9 LRR repeats (leucine-rich repeats) contains 1 NACHT domain

Alternative splicing

named isoforms=2

Expression

• expressed in uterus, ovary > heart, brain
• not expressed in skeletal muscle
• induced by LPS & IL1B in peripheral blood mononuclear cells

Pathology

• defects in NALP7 are the cause of hydatidiform mole

More general terms

• NACHT, LRR & PYD-containing protein (NALP)

Database

• OMIM: https://mirror.omim.org/entry/231090
• UniProt: http://www.uniprot.org/uniprot/Q8WX94.html