protein SETSIP; SET pseudogene protein 18; SET similar protein; similar to SET translocation protein (SETSIP, SETP18)

Function

• role as a transcriptional activator involved in the early stage of somatic cell reprogramming
• promotes differentiation of protein-induced pluripotent stem cells into endothelial cells & the formation of vascular-like tubes (in vitro)
• role in induction of vascular endothelial (VE)-cadherin expression
• associates with VE-cadherin gene promoter

Compartment

• cytoplasm. nucleus
• translocated from the cytoplasm to the nucleus in protein- induced pluripotent stem (PiPS) endothelial cells

Expression

• expressed in endothelial cells (at protein level)
• up-regulated during protein-induced pluripotent stem cell - endothelial cell differentiation
• up-regulated by VEGFA & POU2F1 (at protein level)

Genetics

• probable retrogene derived from SET transcript

Notes

• uncertain whether Met-1 or Met-11 is the initiator

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=646817
• UniProt: http://www.uniprot.org/uniprot/P0DME0.html