transcription factor SPT20 homolog; p38-interacting protein; p38IP (SUPT20H, C13orf19, FAM48A, FP757)

Function

• required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 &/or MAPK14) activation during gastrulation
• required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase & independently of regulation of transcription by FGF signaling & snail (putative)
• required for starvation-induced ATG9A trafficking during autophagy
• interacts with MAPK14
• interacts with ATG9A

Structure

belongs to the SPT20 family

Compartment

nucleus

Alternative splicing

named isoforms=2

Expression

• highly expressed in testis
• moderately in brain & pituitary gland
• expressed in several fetal tissues, including lung, brain, thymus & kidney

Pathology

• expression is down-regulated in prostate cancer

More general terms

• transcription factor (TF)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55578
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55578
• OMIM: https://mirror.omim.org/entry/613417
• UniProt: http://www.uniprot.org/uniprot/Q8NEM7.html