autophagy protein 9-like 1; autophagy-related protein 9A; APG9-like 1; mATG9 (ATG9A, APG9L1)

Function

• role in autophagy
• cycles between a juxta-nuclear trans-Golgi network compartment & late endosomes
• nutrient starvation induces accumulation on autophagosomes
• starvation-dependent trafficking requires ULK1, ATG13 & FAM48A
• interacts with FAM48A

Structure

belongs to the ATG9 family

Compartment

• cytoplasmic vesicle, autophagosome membrane
• multi-pass membrane protein (putative)
• Golgi apparatus, trans-Golgi network membrane
• late endosome membrane

Alternative splicing

• named isoforms=3
• at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

More general terms

• autophagy protein (autophagy-related protein)
• transmembrane 6 protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79065
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79065
• UniProt: http://www.uniprot.org/uniprot/Q7Z3C6.html