mitogen activated protein kinase kinse kinase kinase 4 (MAP4K4, MAPK/ERK kinase kinase kinase 4, MEK kinase kinase 4, MEKKK 4, HPK1/GCK-like kinase, HGK, Nck interacting kinase)

Function

• serine/threonine kinase
• may play a role in the response to environmental stress & cytokines such as TNF-alpha
• appears to act upstream of the JUN N-terminal pathway
• interacts with the SH3 domain of the adapter proteins Nck (putative)
• binds, via its CNH regulatory domain, to the N-terminal region of SPG3A
• phosphorylated upon DNA damage, probably by ATM or ATR

ATP + a protein <--> ADP + a phosphoprotein

Cofactor: Mg+2

Structure

• belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
• contains 1 CNH domain contains 1 protein kinase domain

Alternative splicing

named isoforms=5

Expression

• ubiquitous, expressed in all tissue types examined
• isoform 5 appears to be more abundant in brain
• isoform 4 is predominant in the liver, skeletal muscle & placenta

More general terms

• mitogen activated protein kinase kinse kinase kinase

Database

• OMIM: https://mirror.omim.org/entry/604666
• UniProt: http://www.uniprot.org/uniprot/O95819.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9448