zinc finger CCCH domain-containing protein 12A (MCP-induced protein 1) (ZC3H12A MCPIP MCPIP1)

Function

• transcriptional activator which triggers apoptosis & promotes angiogenesis in response to the binding of CCL2 to CCR2
• regulates expression of CDH12 & CHD19

Structure

• belongs to the ZC3H12 family
• contains 1 C3H1-type Zn+2 finger

Compartment

nucleus

Expression

• induced by cytokines (TNF-alpha & interleukin-1) in acute monocytic leukemia cell line THP-1 cells

Pathology

• increased expression of ZC3H12A is associated with ischemic heart disease

More general terms

• nuclear protein
• zinc finger protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q5D1E8.html