demyelinating disease

Classification

• idiopathic inflammatory CNS demyelinating disorders are defined by their distribution, clinical symptoms, severity & tendency to relapse

Epidemiology

• multiple sclerosis is the most common CNS demyelinating disorder

Comparative biology

• miconazole & clobetasol promote remyelination in mouse demyelinating disease
  • these 2 agents induced mouse oligodendrocyte-progenitor stem cells to turn into myelin-producing oligodendrocytes

More general terms

• neuroinflammatory disease

More specific terms

• acute hemorrhagic leukoencephalopathy
• autosomal dominant adult-onset leukodystrophy (autosomal dominant Pelizaeus-Merzbacher disease)
• central pontine myelinolysis (osmotic demyelination syndrome)
• encephalomyelitis
• inflammatory demyelinating polyneuropathy
• Marchiafava-Bignami disease
• multiple sclerosis (MS); includes clinically isolated syndrome
• Pelizaeus-Merzbacher disease
• progressive multifocal leukoencephalopathy (PML)
• transverse myelitis

Additional terms

• demyelination