cephalosporin, 1st generation

Introduction

Inadequate penetration into CSF.

Indications

• bacterial infections due to susceptiblw gram-positive organisms
• bacterial infections due to susceptible gram-negative organisms
• urinary tract infections caused by E coli
• acute otitis media
• upper respiratory tract infections
  • pharyngitis, tonsillitis
• lower respiratory tract infections
  • pneumonia
• intra-abdominal infections
  • cholangitis
• skin or soft tissue infections
• infectious arthritis, osteomyelitis
• prophylaxis for perioperative infection
  • administer 2 hours preoperatively
• prophylaxis for bacterial endocarditis
• treatment of endocarditis
• empiric treatment for fever of unknown origin

Antimicrobial activity

Gram positive

• Streptococcus
• Staphylococcus

Gram negative

• Escherichia coli
• Proteus
  • Proteus mirabilis
• Klebsiella
  • Klebsiella pneumoniae
• Moraxella catarrhalis
• Haemophilis
  • Haemophilis influenzae
  • Haemophilus parainfluenzae[1]

More general terms

• cephalosporin

More specific terms

• cefadroxil (Duricef, Ultracef)
• cefazolin (Ancef, Kefzol)
• cephalexin (Keflex, Keflet, Panixine)
• cephalothin (Keflin)
• cephapirin (Cefadyl)
• cephradine (Velosef, Anspor)