cefadroxil (Duricef, Ultracef)

Introduction

Tradenames: Duricef, Ultracef. 1st generation cephalosporin.

Indications

• bacterial infections due to susceptible organisms
  • tonsillitis
  • skin or soft tissue infection
• prophylaxis for bacterial endocarditis

Dosage

1-2 g/day divided QD/BID. PO (oral)

Tabs: 500 1000 mg.

Children: 30 mg/kg/day divided BID.

Suspension: 125, 250, 500 mg/5 mL.

Antimicrobial activity

Gram positive

• Streptococcus
  • Streptococcus group A
  • Streptococcus group B
  • Streptococcus group C
  • Streptococcus group G
  • Streptococcus pneumonia
  • Streptococcus viridans, milleri
• Staphylococcus aureus (MSSA)
• Staphylococcus epidermidis (+/-)

Gram negative

• Moraxella catarrhalis
• Escherichia coli
• Klebsiella species
• Proteus mirabilis

More general terms

• cephalosporin, 1st generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2619
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=47964
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=47965
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441194
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282501