cephapirin (Cefadyl)

Introduction

Tradename: Cefadyl. 1st generation cephalosporin. 0.5-2 g IV/IM every 4-6 hours.

Pharmacokinetics

• esterfied to metabolite with 54% activity of parent compound
• metabolite may accumulate with parent compound in renal failure

elimination via kidney

elimination via liver

1/2life = 1.2 hours

protein binding = 58 %

elimination by hemodialysis = +

elimination by peritoneal dialysis = -

Adverse effects

• eosinophilia
• allergic rashes
• fever
• malaise
• headache
• joint & muscle pain
• neutropenia
• transient increase in ALT, AST & alkaline phosphatase

• drug adverse effects of cephalosporins

Test interactions

• positive direct Coomb's test

Laboratory

• specimen:
  • serum
  • keep specimen on ice-water
  • centrifuge at 4 degrees C
  • remove cells as soon as possible
  • freeze at -70 degrees C until assayed
• methods: HPLC, MB

More general terms

• cephalosporin, 1st generation

Database

• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=30699
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2672
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=2616
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=32325
• PubChem: http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=441388