cyclin-D-binding Myb-like transcription factor 1 (hDMTF1, cyclin-D-interacting Myb-like protein 1, hDMP1, DMTF1, DMP1)

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Function

transcriptional activator
activates CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting TP53/p53-dependent growth arrest (putative)
binds to the consensus sequence 5'-CCCG[GT]ATGT-3'
isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene
isoform 2 may antagonize transcriptional activation by isoform 1
interacts with the D-type cyclins CCND1, CCND2 & CCND3 (putative)
interaction with D-type cyclins may modulate transcriptional activation by this protein (putative)
phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 & cyclin-D2/CDK6 complexes & to a lesser extent by the cyclin-D1/CDK4 complex (putative)

expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate & small intestine
expressed at higher levels in spleen, testis & thymus
expressed in multiple regions of the brain & CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra & subthalmic nucleus
isoform 1 is the predominant isoform in monocytes, macrophages & neutrophils
isoform 2 is most strongly expressed in peripheral blood leukocytes & quiescent CD34 positive cells
isoform 3 is expressed at low levels in all hematopoietic cell types
expression of isoform 2 is down-regulated during myeloid differentiation, while the expression of isoform 1 & isoform 3 remain constant

expression is frequently diminished in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haplo-insufficient for tumor suppression
loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF & TP53/p53 loci
hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7