HIV1 enhancer-binding protein 2; transcription factor HIVEP2; HIV-EP2; MHC-binding protein 2; MBP-2 (HIVEP2)

Function

• specifically binds to the DNA sequence 5'-GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV1
• related sequences are found in the enhancer elements of a number of cellular promoters, including those of MHC class 1, IL2 receptor, somatostatin receptor 2, & interferon-beta genes
• may have role in T-cell activation
• interacts with TCF4 (putative)

Structure

contains 4 C2H2-type Zn+2 fingers

Compartment

nucleus

Expression

• expressed in brain & skeletal muscle
• induced by mitogens & phorbol ester

More general terms

• DNA-binding protein
• transcription factor (TF)
• phosphoprotein
• C2H2 type zinc finger protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3097
• OMIM: https://mirror.omim.org/entry/143054
• UniProt: http://www.uniprot.org/uniprot/P31629.html