SMCC mediator complex (mediator of RNA polymerase 2 transcription)

Function

• can either repress or activate transcription
• essential for basal & regulated expression of nearly all RNA polymerase 2-dependent genes
• may act as a bridge, conveying regulatory information from enhancers & other control elements to the promoter
• may act independently of the RNA polymerase 2 CTD.

Structure

• consists of:
  • SURB7, CDK8/SRB10, CCNC/SRB11, MED6, CRSP2/RGR1, SOH1, NUT2, PPARBP/TRAP220 & TRAP100

More general terms

• mediator complex (mediator of RNA polymerase 2 transcription)