programmed cell death 1 ligand 2; PD-1 ligand 2; PD-L2; PDCD1 ligand 2; butyrophilin B7-DC; B7-DC; CD273 (PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2)

Function

• role in costimulatory signaling
• essential for T-cell proliferation & IFNG production
• interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression & cytokine production
• interacts with PDCD1 (putative)

Structure

• belongs to the immunoglobulin superfamily, BTN/MOG family
• contains 1 Ig-like C2-type domain
• contains 1 Ig-like V-type domain

Compartment

• isoform 3: secreted (probable)
• isoform 2: endomembrane system
• isoform 1: cell membrane
• single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

• highly expressed in heart, placenta, pancreas, lung & liver
• weakly expressed in spleen, lymph nodes & thymus
• up-regulated by IFNG/IFN-gamma stimulation in monocytes
• induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 & IL4/interleukin-4

More general terms

• CD antigen
• glycoprotein

Additional terms

• apoptosis

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=80380
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:80380
• OMIM: https://mirror.omim.org/entry/605723
• UniProt: http://www.uniprot.org/uniprot/Q9BQ51.html