myelin-oligodendrocyte glycoprotein (MOG)

Function

• minor component of the myelin sheath
• may be involved in completion &/or maintenance of the myelin sheath & in cell-cell communication

Structure

• may form homodimers or heterodimers between the different isoforms
• belongs to the immunoglobulin superfamily, BTN/MOG family
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

• cell membrane
• isoforms 1,,5 multi-pass membrane protein (putative)

Alternative splicing

named isoforms=9 Additional isoforms seem to exist some isoforms may not be functionally active, or may be expressed at low level in adults

Expression

• found exclusively in the CNS, where it is localized on the surface of myelin & oligodendrocyte cytoplasmic membranes

Pathology

• myelin oligodendrocyte glycoprotein disease

Laboratory

• myelin-oligodendrocyte glycoprotein IgG in serum/plasma

Notes

• do not confuse with oligodendrocyte-myelin glycoprotein

More general terms

• myelin protein
• glycoprotein
• immunoglobulin superfamily protein

Additional terms

• oligodendrocyte-myelin glycoprotein (OMG OMGP)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4340
• OMIM: https://mirror.omim.org/entry/159465
• UniProt: http://www.uniprot.org/uniprot/Q16653.html