programmed cell death protein 1; PDL1 receptor; protein PD-1; CD273 receptor; CD274 receptor; hPD-1 (PDCD1, hPD-1, CD279)
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Function
- possible cell death inducer in association with ligands CD273 & CD274 (PD-L1)
- inhibitory receptor expressed by T-cells
Structure
- contains 1 Ig-like V-type domain
Compartment
- membrane; single-pass type 1 membrane protein
Expression
- expressed by T-cells
- induced at programmed cell death
Pathology
- genetic variation in PDCD1 is associated with susceptibility to systemic lupus erythematosus type 2
- expression on HIV1-specific T-cells is associated with T-cell exhaustion & disease progression[2]
Pharmacology
- anti-PDCD1 antibody benefits 18-27% of patients with non-small-cell lung cancer, cutaneous melanoma or renal cell carcinoma[3]
- pembrolizumab (Keytruda) & nivolumab (Opdivo) block ligand activation of the PD-1 receptor on activated T cells
- PDCD1 is an inhibitory receptor expressed on activated tumor-specific CD4+ helper T-cells & CD8+ cytotoxic T-cells
- its major ligand PD-L1 is expressed in many human cancers[3]
More general terms
Additional terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q15116.html
- ↑ 2.0 2.1 Day CL et al, PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16921384
- ↑ 3.0 3.1 3.2 Topalian SL et al Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer N Engl J Med, June 2, 2012 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/22658127 <Internet> http://www.nejm.org/doi/full/10.1056/NEJMoa1200690
Database
- Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5133
- Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5133
- OMIM: https://mirror.omim.org/entry/109100
- OMIM: https://mirror.omim.org/entry/600244
- OMIM: https://mirror.omim.org/entry/605218
- UniProt: http://www.uniprot.org/uniprot/Q15116.html