CD109 antigen; C3 & PZP-like alpha-2-macroglobulin domain-containing protein 7; 150 kD TGF-beta-1-binding protein; platelet-specific Gov antigen; human platelet antigen 15; HPA-15; p180; r150 (CD109, CPAMD7)

Function

• modulates negatively TGFB1 signaling in keratinocytes
• interacts with TGFB1 & TGFBR1
• forms a heteromeric complex with TGFBR1, TGFBR2 & TGFBR3 (ligand-dependent)

Structure

• heterodimer, disulfide-linked.
• glycophosphatidylinositol-linked glycoprotein
• carries platelet-specific Gov antigen system

Compartment

cell membrane, GPI-anchor

Alternative splicing

named isoforms=4

Expression

• widely expressed, including uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen, lung
• subset of hematopoietic stem & progenitor cells
• activated platelets & T cells
• endothelial cells, keratinocytes

Pathology

• implicated in
  • refractoriness to platelet transfusion
  • neonatal alloimmune thrombocytopenia
  • posttransfusion purpura
• expressed by CD34+ acute myeloid leukemia cell lines

Laboratory

• HPA-15 type in blood

More general terms

• CD antigen
• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=135228
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:135228
• OMIM: https://mirror.omim.org/entry/608859
• UniProt: http://www.uniprot.org/uniprot/Q6YHK3.html