betaglycan; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor III (TGFBR3)

Function

• binds to TGF-beta
• possible role in capturing & retaining TGF-beta for presentation to signaling receptors
• interacts with TCTEX1D4
• extensively modified by glycosaminoglycan groups (GAG)
• membrane bound & soluble forms with opposite effects on TGF-beta signaling; membrane bound form enhances TGF-beta binding to TGF-beta receptor complex; soluble form inhibits TGF-beta action
• membrane bound betaglycan also can inhibit activin signaling by forming complex with inhibin & ActRIIB

Structure

contains 1 ZP domain

Compartment

• cell membrane
• secreted, extracellular space, plasma, extracellular matrix

More general terms

• tgf beta receptor
• membrane protein
• proteoglycan core protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7049
• OMIM: https://mirror.omim.org/entry/600742
• UniProt: http://www.uniprot.org/uniprot/Q03167.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7049