transforming Growth Factor [TGF]-beta receptor complex
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Introduction
TGF-beta binding induces TGF-beta receptor II subunit phosphorylation & activation of TGF-beta receptor I (ALK5) subunit in most cells, resulting in autophosphorylation & phosphorylation of target proteins.
TGF-beta can also bind to and transduce signals through ALK1 (instead of ALK5). ALK1 is expressed predominantly in endothelial cells.
TGF-beta receptor II - ALK5 complex signals through smad2 or smad3. TGF-beta receptor II - ALK1 complex signals through smad1 or smad5.
Besides TGF-beta, other proteins that react with the TGF-beta receptor complex include FKBP12, TRIP1, STRAP & B-alpha subunit of protein phosphatase 2A
More general terms
Additional terms
- betaglycan; TGF-beta receptor type III; TGFR-3; transforming growth factor beta receptor III (TGFBR3)
- transforming growth factor [TGF]-beta
References
- ↑ Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet. 2001 Oct;29(2):117-29. Review. Erratum in: Nat Genet 2001 Nov;29(3):351. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11586292