serine/threonine protein kinase receptor R3; SKR3; activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I (ACVRL1 ACVRLK1 ALK1)

Function

• receptor for TGF-beta
• may bind activin as well
• on ligand binding, forms a receptor complex consisting of 2 type II & 2 type I transmembrane serine/threonine kinases
• type II receptors phosphorylate & activate type I receptors which autophosphorylate, then bind & activate SMAD transcriptional regulators

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 GS domain
• contains 1 protein kinase domain

Compartment

membrane

Pathology

• defects in ACVRL1 are the cause of Osler-Weber-Rendu syndrome 2

More general terms

• serine/threonine kinase receptor
• activin receptor like kinase (ALK)
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:94;
• OMIM: https://mirror.omim.org/entry/600376
• OMIM: https://mirror.omim.org/entry/601284
• UniProt: http://www.uniprot.org/uniprot/P37023.html