activin receptor type-2B; activin receptor type IIB; ACTR-IIB (ACVR2B)

Function

• on ligand binding, forms a receptor complex consisting of two type 2 & two type 1 transmembrane Ser/Thr kinases
• type 2 receptors phosphorylate & activate type 1 receptors which autophosphorylate, then bind & activate SMAD (SMAD2 & SMAD3 transcriptional regulators
• receptor for activin A, activin B & inhibin A
• interacts with myostatin

Cofactor: Mg+2 or Mn+2 (putative)

Structure

• belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
• contains 1 protein kinase domain

Compartment

membrane

Alternative splicing

named isoforms=2

Pathology

• defects in ACVR2B are a cause of left-right axis malformations

More general terms

• activin receptor
• glycoprotein
• serine/threonine kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:93
• OMIM: https://mirror.omim.org/entry/602730
• UniProt: http://www.uniprot.org/uniprot/Q13705.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=93