DCC-interacting protein 13 alpha; Dip13 alpha, adapter protein containing PH domain; PTB domain & leucine zipper motif 1 (APPL1, APPL, DIP13A, KIAA1428)

Function

• regulation of cell proliferation
  • response to extracellular signals
  • mediated by an early endosomal compartment
• links Rab5 to nuclear signal transduction
• binds RAB5A leading to recruitment to endosomal membranes & role in cell proliferation
• binds DCC
• binds catalytic domain of the inactive form of AKT2 through PID domain
• binds PIK3CA
• binds subunits of the NuRD/MeCP1 complex
• overexpression has proapoptotic effect
• interacts with OCRL & INPP5B

Structure

• the F&H motif, an approximately 12-13 amino-acid sequence centered around Phe & His residues, is essential for binding to OCRL & INPP5B
• contains 1 PH domain
• contains 1 PID domain

Compartment

• early endosomal membrane, peripheral membrane, nucleus
• translocation into the nucleus upon release from endosomal membranes following internalization of EGF

Expression

• expressed in heart, ovary, pancreas, skeletal muscle

More general terms

• membrane protein
• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26060
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26060
• OMIM: https://mirror.omim.org/entry/604299
• UniProt: http://www.uniprot.org/uniprot/Q9UKG1.html