inositol-1,3,4,5-tetraphosphate-5-phosphatase; inositol polyphosphate 5-phosphatase type II

Function

• hydrolyzes the Ca+2-mobilizing second messenger IP3; this is a signal-terminating reaction

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O
                     <-->
1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

Structure

• belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type 2 family
• contains 1 Rho-GAP domain

Alternative splicing

named isoforms=4

Expression

platelets

More general terms

• phosphomonoesterase

Database

• UniProt: http://www.uniprot.org/uniprot/P32019.html
• OMIM: https://mirror.omim.org/entry/147264
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3633