cytokine receptor-like factor 2 (cytokine receptor-like 2, CRL2, IL-XR, thymic stromal lymphopoietin protein receptor, TSLPR, CRLF2, ILXR)
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Function
- receptor for thymic stromal lymphopoietin (TSLP)
- forms functional complex with TSLP & IL7R which stimulates cell proliferation through activation of STAT3 & STAT5
- activates JAK2
- role in development of hematopoietic system
Structure
- belongs to the type I cytokine receptor family, type 5 subfamily
- WSXWS motif appears necessary for proper protein folding & thus efficient intracellular transport & cell-surface receptor binding
- box 1 motif is important for association with JAKs
- contains 1 fibronectin F3 module
Compartment
- isoform 1: cell membrane
- isoform 2: secreted
Alternative splicing
named isoforms=2
Expression
- expressed in heart, skeletal muscle, kidney & adult & fetal liver
- primarily expressed in monocytes & dendritic cells ?
- weakly expressed in T-cells
- up-regulated in activated peripheral monocytes & THP-1 cells
Genetics
- gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1) of X & Y chromosomes