CD127; CDw127; interleukin-7 [IL-7] receptor-alpha (IL7RA, IL7R)
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Function
- receptor for interleukin-7
- heterodimer of an alpha chain & a common gamma chain
Structure
- WSXWS motif appears to be necessary for proper protein folding & thereby efficient intracellular transport & cell-surface receptor binding
- box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 4 subfamily
- contains 1 fibronectin F3 module
Compartment
Alternative splicing
Expression
Pathology
- polymorphism(s) in IL7R (alpha) associated with risk of multiple sclerosis
More general terms
Additional terms
Component of
References
- ↑ Krantz SB. Erythropoietin. Blood. 1991 Feb 1;77(3):419-34. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1991159
- ↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
- ↑ Ihle JN et al Signaling by the cytokine receptor superfamily: JAKs and STATs TIBS 19:222 1994 PMID: https://www.ncbi.nlm.nih.gov/pubmed/8048164
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3575
- ↑ GeneReviews; https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL7R
- ↑ UniProt http://www.uniprot.org/uniprot/P16871.html
- ↑ 7.0 7.1 Passtoors WM Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R. PLoS One. 2012;7(1):e27759. Epub 2012 Jan 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/22247756