mannan-binding lectin serine protease 1; complement factor MASP-3; complement-activating component of Ra-reactive factor; mannose-binding lectin-associated serine protease 1; MASP-1; mannose-binding protein-associated serine protease; Ra-reactive factor serine protease p100; RaRF; serine protease 5; contains: mannan-binding lectin serine protease 1 heavy chain; mannan-binding lectin serine protease 1 light chain (MASP1, CRARF, CRARF1, PRSS5)

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Function

interacts with the oligomeric lectins MBL2, FCN2 & FCN3; triggers the lectin pathway of complement through activation of complement-C3

interacts with SERPING1

Kinetic parameters:

Structure

Compartment

secreted

Alternative splicing

named isoforms=4

Expression

  • protein of the plasma which is primarily expressed by liver

Pathology

Polymorphism

  • variant in position: 497:H->Y (in 3MC1)
  • variant in position: 630:C->R (in 3MC1)
  • variant in position: 666:G->E (in 3MC1)

More general terms

Additional terms

References

Database