ficolin-3; collagen/fibrinogen domain-containing lectin 3 p35; collagen/fibrinogen domain-containing protein 3; Hakata antigen (FCN3, FCNH, HAKA1)

Function

• may function in innate immunity through activation of the lectin complement pathway
• Ca+2-dependent & GlcNAc-binding lectin
• has affinity with galNAc, GlcNAc, D-fucose, as mono/oligosaccharide & lipopolysaccharides from S typhimurium & S minnesota
• interacts with MASP1 & MASP2
• does not interact with fibronectin, elastin or zymosan

Structure

• the N-terminus is blocked
• homopolymer; disulfide-linked
• may be an octadecamer consisting of an elementary trimer unit
• belongs to the ficolin lectin family
• contains 1 collagen-like domain
• contains 1 fibrinogen C-terminal domain

Compartment

• secreted
• found in blood plasma, bronchus, alveolus & bile duct

Alternative splicing

named isoforms=2

Expression

• expressed in liver & lung
• in liver it is produced by bile duct epithelial cells & hepatocytes
• in lung it is produced by both
  • ciliated bronchial epithelial cells
  • type II alveolar epithelial cells

Pathology

• defects in FCN3 are the cause of ficolin 3 deficiency

More general terms

• ficolin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8547
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8547
• OMIM: https://mirror.omim.org/entry/604973
• OMIM: https://mirror.omim.org/entry/613860
• UniProt: http://www.uniprot.org/uniprot/O75636.html