ficolin-2; 37 kD elastin-binding protein; collagen/fibrinogen domain-containing protein 2; EBP-37; Ficolin-B; Ficolin-beta; Hucolin; L-ficolin; serum lectin p35 (FCN2 FCNL)

Function

• may function in innate immunity through activation of the lectin complement pathway
• Ca+2-dependent & GlcNAc-binding lectin
• enhances phagocytosis of S typhimurium by neutrophils, suggesting an opsonic effect via the collagen region
• interacts with elastin
• interacts with MASP1 & MASP2

Structure

• homopolymer; disulfide-linked
• the fibrinogen-like domain (FBG) contains potential Ca+2-binding sites that may be involved in carbohydrate binding
• belongs to the ficolin lectin family
• contains 1 collagen-like domain
• contains 1 fibrinogen C-terminal domain

Compartment

secreted

Alternative splicing

named isoforms=2

Expression

• expressed by the liver & secreted into plasma

More general terms

• ficolin

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2220
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2220
• OMIM: https://mirror.omim.org/entry/601624
• UniProt: http://www.uniprot.org/uniprot/Q15485.html