complement C1 inhibitor; C1 esterase inhibitor (SERPING1, Cinryze, Berinert)
Jump to navigation
Jump to search
Function
- C1 inhibitor inhibits:
Structure
35% carbohydrate
Pathology
- deficiency associated with hereditary angioneurotic edema
Pharmacology
Indications
- prevention of hereditary angioedema attacks
Laboratory
Notes
- Cinryze twice weekly IV infusion costs > US $300,000 annually
- a subcutaneous C1 inhibitor twice weekly is effective[4]
More general terms
More specific terms
Additional terms
References
- ↑ OMIM https://mirror.omim.org/entry/106100
- ↑ 2.0 2.1 ARUP Consult: Hereditary Angioedema - C1-INH Deficiency The Physician's Guide to Laboratory Test Selection & Interpretation https://www.arupconsult.com/content/hereditary-angioedema
- ↑ ARUP Consult: C1-INH Deficiency Testing Algorithm The Physician's Guide to Laboratory Test Selection & Interpretation https://arupconsult.com/algorithm/c1-inh-deficiency-testing-algorithm
- ↑ 4.0 4.1 Longhurst H, Cicardi M, Craig T et al. Prevention of hereditary angioedema attacks with a subcutaneous C1 inhibitor. N Engl J Med 2017 Mar 23; 376:1131 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/28328347 <Internet> http://www.jwatch.org/na43697/2017/03/23/new-preventive-treatment-hereditary-angioedema