insulin-like growth factor-binding protein 5; IBP-5; IGF-binding protein 5; IGFBP-5 (IGFBP5 IBP5)

Function

• IGF-binding proteins prolong the half-life of the IGFs
• they either inhibit or stimulate the growth promoting effects of the IGFs on cell culture
• they alter the interaction of IGFs with their cell surface receptors

Structure

• contains 1 IGFBP N-terminal domain
• contains 1 thyroglobulin type-1 domain

Compartment

secreted

Expression

• expressed in osteosarcoma
• expressed at lower levels in liver, kidney & brain

More general terms

• insulin-like growth factor [IGF]-binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3488
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3488
• OMIM: https://mirror.omim.org/entry/146734
• UniProt: http://www.uniprot.org/uniprot/P24593.html