Na+ channel protein type 11 subunit alpha; Na+ channel protein type XI subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.9; sensory neuron Na+ channel 2; peripheral nerve Na+ channel 5; hNaN (SCN11A, PN5, SCN12A, SNS2)
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Function
- mediates voltage-dependent Na+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across the membrane
- forms a Na+-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient
- tetrodotoxin-resistant Na+ channel isoform
- role in association with receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization
- voltage-resistant Na+ channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B & SCN3B
Structure
- contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) & one positively charged segment (S4)
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the Na+ channel family
Compartment
membrane
Alternative splicing
named isoforms=3
Expression
- expressed in the dorsal root ganglia, trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine & placenta
More general terms
- transmembrane 24 protein
- voltage-dependent Na+ channel protein alpha subunit
- phosphoprotein
- glycoprotein